roller compaction of moist pharmaceutical powders

Make more of moisture

2020-6-2In the pharmaceutical industry the three common granulation processes for solid dosage form production are wet granulation dry granulation (roller compaction) and direct blending and the dry powder particles adhere to the tacky nuclei/mass to create moist agglomerates The process of adding a liquid solution to powders involves the

An Overview of the Effect of Moisture on Compaction and

2017-8-2750 Pharmaceutical Technology JANUARY 2005 DATA REVIEW than for dry powders at low-compression pressures A powder bed's tensile strength with a shear cell (which can be obtained from measurements of the packed powder bed's shear strength) and the influence of mois-ture content on the flow properties of pow-

Make more of moisture

2020-6-2In the pharmaceutical industry the three common granulation processes for solid dosage form production are wet granulation dry granulation (roller compaction) and direct blending and the dry powder particles adhere to the tacky nuclei/mass to create moist agglomerates The process of adding a liquid solution to powders involves the

Moisture

2018-3-14In the pharmaceutical industry the three most common granulation processes for solid dosage form production are wet granulation dry granulation (roller compaction) and direct blending Yet despite being well-established techniques each has its drawbacks Moisture-activated dry granulation (MADG) was developed in response to the difficulties

Roll compaction of pharmaceutical excipients

Experimental investigations of roll compaction of pharmaceutical powders were established in 1960s (Cohn et al 1966 Jaminet and Hess 1966) Cohn et al (1966) attempted to optimise the roll compaction process to prepare granules to which other drugs could be added and directly compressed into tablets using a Fitzpatrick roll compactor

Roller Compactors for the Chemical Industry

Roller Compactor PP150 Throughput up to 300kg/hr PowerPactor PP175VN Throughput up to 2 400kg/hr PowerPactor PP250VN The PowerPactor PP250VN made by Alexanderwerk is the optimum roller compac-tor for efficient compaction of large volumes of material With a throughput of up to 5 000kg/hr the PowerPactor PP250VN is just the right machine

Linking API Material Property in High Load

2020-1-15Roller compaction (RC) is a granulation technique utilised in the pharmaceutical industry to improve the flow of powders It is especially useful for APIs which are heat and/or moisture sensitive However due to a phenomenon termed loss of reworkablilty RC often results in a reduction of tablet tensile strength (TS)

Pharmaceutical granules

Pharmaceutical powders that were mixed homogeneouslyPharmaceutical powders that were mixed homogeneously together are compressed to obtain large tablets together are compressed to obtain large tablets Roller compaction (see industrial pharmacy) Roller compaction (see industrial pharmacy) which was absorbed by a drug present in a moist

Prof Jonathan Seville

2020-8-13BiographyProfessor Jonathan Seville is President of the Institution of Chemical Engineers 2016-2017 He was Executive Dean of the Faculty of Engineering and Physical Sciences at the University of Surrey 2011-2016 Jonathan has degrees in Chemical Engineering from the Universities of Cambridge and Surrey and has held visiting appointments at the University of British Columbia and the Technical

Powders and Granules Flashcards

Pharmaceutical preparations: topical powder or sterile powder in vial 3 Starting material for -Moist and mix powders to form liquid bridge among powders-Powders stick together in lumps Roller Compaction -Powder blend is compressed between rollers to form a cake (ribbon) -Cake milled to form granules

Granulation techniques and technologies: recent

2018-11-4Recent progress in dry granulation Dry granulation could be achieved either by roller compaction or by slugging The two different types are illustrated in the schematic diagram Fig 2 There has not been much progress in the dry granulation technique and technology in comparison to wet granulation except for one important innovation known as pneumatic dry granulation technology

Benefits of wet conditioning prior to drying

2020-4-30Benefits of wet conditioning prior to drying pharmaceutical powders Published on Apr 30 2020 1:34:03 PM While looking into ways to improve overall product quality and reduce the production of fines a pharmaceutical manufacturer experimented with various methods of conditioning the wet granulate at the start of the manufacturing process

Prof Jonathan Seville

2020-8-13BiographyProfessor Jonathan Seville is President of the Institution of Chemical Engineers 2016-2017 He was Executive Dean of the Faculty of Engineering and Physical Sciences at the University of Surrey 2011-2016 Jonathan has degrees in Chemical Engineering from the Universities of Cambridge and Surrey and has held visiting appointments at the University of British Columbia and the Technical

Wet Granulation reduces drying times by up to 60%

2019-11-29Pharmaceutical companies worldwide have been using the Comil for removing lumps from pharmaceutical wet masses prior to the drying process In the tablet manufacturing process powders such as lactose the active ingredient binders and water or solvent are mixed to form a wet mass This process can be carried out in various types of mixers

Charley Wu

Roller compaction of moist pharmaceutical powders International Journal of Pharmaceutics May 2010 Other authors See publication ESR8: DEM and FEM modelling of die filling and compaction of powders and granules (Fraunhofer Institute for Mechanics of Materials IWM Germany)

Roller compaction of moist pharmaceutical powders

The moist powders were then compacted using the instrumented roller compactor developed at the University of Birmingham The flow and compression behaviour during roller compaction and the properties of produced ribbons were examined It has been found that as the moisture content increases the flowability of moist MCC powders decreases and

An Overview of the Effect of Moisture on Compaction and

2017-8-2750 Pharmaceutical Technology JANUARY 2005 DATA REVIEW than for dry powders at low-compression pressures A powder bed's tensile strength with a shear cell (which can be obtained from measurements of the packed powder bed's shear strength) and the influence of mois-ture content on the flow properties of pow-

Prof Charley Wu

2020-8-13Prof Chuan-Yu (Charley) Wu is a professor in Chemical Engineering at the Department of Chemical and Process Engineering and the coordinator of the Unilever-IPE-Surrey collaborative doctoral training programme in sustainable manufacture multi-scale modelling formulation and product engineering He was also the coordinator of a EU FP7 Initial Training Network (ITN) consortium

ceutics 2

dry granulation: Roller compaction The powder blend is passed through the rolls of a roller compactor exerting certain roll force which compacts the powder to form ribbons The surface of the rolls can be smooth serrated sine coaxial etc which gives different forms and textures of ribbons

Effervescent Dosage Manufacturing

Effervescent tablets are an interesting pharmaceutical dosage form offering some unique advantages when compared with simple tablets However the manufacturing process involves some critical steps that need to be addressed carefully during formulation and factory design

Wet Granulation Process : Pharmaceutical Guidelines

2020-8-18Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid The fluid contains a solvent which can be removed by drying and should be non-toxic Typical solvents include water ethanol and isopropanol and methylene chloride either alone or in combination The granulation liquid may be used alone or more usually as a solvent containing a

Pharmaceutics

Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders separately However the comparison of the performance of these two types of powders during twin screw wet

Applications

[:en]PRODUCTS APPLICATIONS In which applications do we deliver? Alexanderwerk Roller Compactors are found nowadays in a wide range of applications From the production of antibiotics to the compaction of battery masses to the compaction of metal oxides Alexanderwerk supports customers worldwide in the production of high-quality granulates

Pharmaceutics

Roller compaction can be used for moisture sensitive and heat sensitive faster manufacturing Roller compaction particle bonding process Inter-particle bond formation particle rearrangment loss of air inc in density particle fragmentation and deformation creation of new surfaces potential bonding sites

Roller Compaction of Hydrophilic Extended Release

The present study shows that roller compaction (RC) can successfully be used as a granulation method to prepare hydroxypropyl methylcellulose (HPMC)-based extended release matrix tablets containing a high drug load both for materials deforming mainly by fragmentation (paracetamol) as for those having mainly plastic deformation (ibuprofen) The combined effect of RC process variables and

Roller compaction of moist pharmaceutical powders

2010-5-31The flowability of these samples were evaluated in terms of the poured angle of repose and flow functions The moist powders were then compacted using the instrumented roller compactor developed at the University of Birmingham The flow and compression behaviour during roller compaction and the properties of produced ribbons were examined